Hyperspectral Imaging has long been established in other scientific disciplines than medicine (e.?g. earth science) as a means for objective classification of image data information. Some 10 years ago it was first introduced into medicine. Due to its immanent advantages – non-destructive specimen, compatibility with established optical tools (microscope, endoscope), objectivity, and user-independence – several attempts have been made in order to use its potential for the treatment of cancer patients. This publication reviews which methods have been developed for analogue issues in disciplines other than medicine, how these can be transferred into medicine, and what the perspectives are for the traditional innovative field of head-and-neck-oncology.